Osteoarthritis (OA) is an enlightened disorder of cartilage degradation, synovial inflammation osteophytes formation thinning of joint space and sub-chondral sclerosis. Cartilage act as cushion between the bones of joints and prevent the rubbing of bones on each other. In between two cartilage of bone joint, synovial fluid filled, which secreted by synovial membrane for lubrication of the joints. OA leads to pain, disability as well as difficulty in joints and restrict the routine movements of human beings 
Methods: Study Design: An Open label single arm Trial 100 cases of Osteoarthritis were randomly recruited and followed up for 3 months. The diagnosis was based on clinical examination & radiography. The Homoeopathic medicines were prescribed on the basis of totality of symptoms with the help of BBCR. Potency selection, dosage & repition of medicine were done according to 5th and 6th edition of Organon of Medicine respectively. The assessment of utility of homoeopathic medicine selected with the help of BBCR in OA cases by using NPRS.
Results: NPRS before and after score concludes effectiveness of treatment with significant improvement in pain with individualized Homoeopathic medicine selected with the help of BBCR.
Conclusion: Homoeopathic medicine offers significant relief in pain management to patients suffering from Osteoarthritis. Homoeopathic medicines were selected with the help of BBCR on the basis of symptoms.