Abstract: The systematic examination of the poisoning in living and dead person is one of the most challenging tasks in forensic toxicology. In the suspected case of poisoning, case history and autopsy findings are very helpful, external and internal examination of the body is carried out to determine the cause of death. Case history, circumstantial evidences and autopsy findings become important part too in this review; information has been assembled on the basis of external and internal finding in live and dead case as well. On the basis of duration of exposure, sign and symptoms, medical practitioner can categorize the poisoning in fulminate, acute, and chronic.