Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disorder mainly affecting the axial skeleton. It has symptoms ranging from low back pain to joint stiffness & immobility which hamper the quality of life of a patient. Conventional mode of treatment has its own limitations in the management of this disease. Here is an attempt to focus on the role of homoeopathy in the management of ankylosing spondylitis.