International Journal of Homoeopathic Sciences

Background: Diabetes Mellitus is metabolic disorder characterized by hyperglycemia resulting from inadequate insulin secretion, insulin inaction or both and insulin resistance. People living with Type-2 DM are more vulnerable to various forms of both short-term and long-term complications, which often lead to their premature death. Gymnema sylvestre, in various homoeopathic preparations, have reported beneficial effect for treating in Type-2 diabetes mellitus.

Aim and Objective: To understand the efficacy of Gymnema sylvestre in 50milisimal potency and in mother tincture on diabetes mellitus Type-2 patients.

Method: This prospective, open label, randomized controlled trial was conducted at OPD and IPD of Government Homoeopathic Medical College and Hospital, Bhopal and camps organized by department. A total 60 nos. of patients were enrolled for this study considering all ethical criteria and inclusion and exclusion criteria’s as per institutional guidelines with 30 cases allotted randomly to GSMT and LM group. Data were recorded on standard case proforma, and entered Microsoft® Excel worksheet 2019, and exported into SPSS v21. 0 (IBM, USA) for statistical analysis. Each case was followed up for a period of six months and outcome were assessed on QOLID scale. Normality of data was determined using Shapiro-Wilk test. Normally distributed variables were compared between two groups using independent t-test. Comparison within a group at two time-intervals was made using paired t-test. P value <0.05 was considered statistically significant.

Results: A significant difference in HbA1c levels in GSMT group compared to LM group at 6-month (6.77±0.41 vs. 7.13±0.27; P=0.003) was observed in this study, also a significant improvement in QOLID levels in GSMT group compared to LM group at 6-month (127.90±7.15 vs 115.20±3.38; P=<0.0001) was observed.

Conclusion: Homoeopathic preparations of Gymnema sylvestre is proved to effective in management of diabetes mellitus though it was observed that gymnema sylvestre mother tincture has more effective.