Abstract: Gluten sensitive enteropathy also known as Celiac disease, an autoimmune disorder which occurs in the presence of HLA DQ2 & HLA DQ8 gene in genetically susceptible individuals. Homoeopathy can direct the treatment constitutionally and therapeutically. Gliadin a derivative of gluten is modified by TTG which is seen as an antigen to the Antigen presenting cells. The enteropathy can also lead to failure to thrive.