Systemic Lupus Erythematosus (SLE) is an autoimmune condition that affects multiple systems and it causes mild problems like skin rashes, and arthritis to severe ailments like lupus nephritis, neuropsychiatric problems, and other organ issues. There is an involvement of genetic aspect to lupus affinity. The worldwide incidence of SLE is around 5.14 per 1, 00,000 person-years. The treatment of SLE involves the use of non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, or immunosuppressants. These multiple conventional treatments for SLE may require extreme adherence and patient compliance which may not be most patients. Moreover, the side effects involved in the use of such drugs are extensive so often patient feels hopeless and stops medications on his own. In such hopeless cases, homeopathy offers a ray of hope and brings along effective treatment of diseases in a natural and sustainable way without any side effects. In this paper, a long-standing case of a 40-year-old male patient with systemic lupus erythematosus and its various complications like venous ulcers, arthritis, acute renal failure, etc., and the effective treatment that was given to the patient that resulted in marked improvement in the patient. Homeopathic medicine helps in the enhancement of the immune function of an individual so that there is a reduction in the intensity of the symptoms.