Plasma Cell Cheilitis is a rare lip disorder characterized by persistent ulcers, often challenging to manage through conventional means, this paper delves into the unique case of a 53-year-old suffering from persistent mouth ulcers, particularly a non-healing ulcer on the lower lip for over two years. Despite conventional treatments yielding no improvement and, in fact, witnessing deterioration in the condition, the individual turned to homeopathic intervention. The patient's discomfort was significantly alleviated within the first Month of homeopathic treatment. The paper aims to shed light on the effectiveness of homeopathy in managing Plasma Cell Cheilitis, offering a holistic healing approach.