International Journal of Homoeopathic Sciences

This review explores the use and role of centesimal potencies within the framework of homeopathic medicine, a therapeutic system based on the principle of "like cures like." Centesimal potencies, prepared through a process of serial dilution and succussion in a 1:100 ratio, form the cornerstone of classical homeopathic practice. Introduced by Samuel Hahnemann, the founder of homeopathy, these potencies are employed in varying degrees from low (e.g., 6C) to ultra-high (e.g., 1M, 10M) based on the nature of the disease, the patient’s constitution, and the depth of symptoms.

The review outlines the historical development, classification, and clinical application of centesimal potencies, including factors influencing potency selection, dosing frequency, and response monitoring. It also examines the theoretical underpinnings proposed to explain their action, such as the concepts of vital force, water memory, and nano-structuring, while acknowledging the controversies and criticisms surrounding their scientific validity particularly at dilutions beyond Avogadro’s limit.

Furthermore, the paper reviews available clinical evidence, highlighting both supportive case studies and the challenges of methodological rigor in homeopathic research. The discussion emphasizes the continued relevance of centesimal potencies in contemporary homeopathic practice and calls for more robust scientific inquiry to bridge the gap between traditional principles and modern biomedical understanding.