International Journal of Homoeopathic Sciences

Background: The European wolf spider, Lycosa tarantula, said to have caused the historical phenomenon of 'tarantism', is the official medicinal source of the homeopathic remedy Tarentula hispanica which is traditionally used in cases marked by hyperactivity, hysteria, and chorea, its pathogenesis shows striking similarities with its toxicological profile, warranting a deeper scientific exploration.

Objective: To explore the cellular and systemic mechanisms of action of the bioactive components of Tarentula hispanica venom and correlate them with homeopathic symptomatology and clinical utility, thereby strengthening its evidence-based application.

Methods: A descriptive and analytical review was undertaken using published toxicological literature, classical homeopathic Materia medica, pharmacological data on spider venom peptides, and recent clinical studies. Data from homeopathic provings and multicentric verification programs were also included to support therapeutic claims.

Results: Neurotoxic peptides in Tarentula hispanica venom modulate ion channels, especially sodium and calcium channels, leading to neuronal hyperexcitability, involuntary movements, and sensory hyper-responsiveness. These effects mirror homeopathic symptoms such as restlessness, choreiform motions, destructiveness, and increased sensitivity. Clinical observations support its utility in ADHD, hysteria, and behavioral disorders.