International Journal of Homoeopathic Sciences

Background: Separation Anxiety Disorder (SAD) is a disabling anxiety disorder often resistant to conventional treatments. Alternative therapies such as Bach Flower remedies and homoeopathy are increasingly explored, but comparative data are scarce.

Objective: To evaluate the comparative efficacy of Bach Flower Mimulus, Aconitum napellus, and individualized homoeopathic medicine in the management of SAD using the Hamilton Anxiety Rating Scale (HAM-A).

Methods: A randomized, assessor-blinded, three-arm clinical trial was conducted on participants (n =) diagnosed with SAD. Group A received Mimulus (Bach Flower remedy), Group B received Aconitum napellus 30C, and Group C received individualized homoeopathic prescriptions. Interventions continued for 6 weeks. The primary outcome was change in HAM-A from baseline. Secondary outcomes included Clinical Global Impression scales (CGI-I, CGI-S), separation-specific checklist, sleep quality, and safety.

Results: All groups showed significant improvement in HAM-A scores (p < 0.05). Group C (individualized homoeopathy) showed the greatest reduction in HAM-A (mean change = –16.4 ± 5.2) compared with Group A (Mimulus, –11.2 ± 4.8) and Group B (Aconitum, –9.8 ± 5.0). Response rates (≥50% HAM-A reduction) were 72% in individualized, 48% in Mimulus, and 40% in Aconitum groups. Remission (HAM-A ≤7) was highest in the individualized group (60%). All interventions were safe and well tolerated.

Conclusion: Individualized homoeopathic medicine is significantly more effective than Mimulus and Aconitum napellus in reducing anxiety symptoms in SAD. Findings highlight the importance of individualized prescribing in clinical homoeopathy.