International Journal of Homoeopathic Sciences

Objective: This study aimed to evaluate and compare the effectiveness of homoeopathic constitutional medicines in centesimal and 50 millesimal potencies for the treatment of knee osteoarthritis (OA). The primary focus was to assess changes in pain, stiffness, swelling, and functions of daily living in OA knee patients using these two potencies.

Methods: A non-randomized control trial was conducted with 40 patients diagnosed with OA of the knee, aged between 40-60 years, who attended the outpatient and inpatient departments of Government Homoeopathic Medical College, Thiruvananthapuram. Patients were alternately assigned to receive homoeopathic treatment in centesimal potency or 50 millesimal potency. The Knee Injury and Osteoarthritis Outcome Score (KOOS) was used to measure the improvement in symptoms, stiffness, pain, functions of daily living, recreational activities, and quality of life.

Results: The findings revealed a significant improvement in pain, swelling, stiffness, and daily function in both groups. However, the 50 millesimal potency group showed slightly greater improvements compared to the centesimal potency group, particularly in the total KOOS score and quality of life.

Conclusion: Homoeopathic constitutional medicines in both centesimal and 50 millesimal potencies demonstrated significant effectiveness in treating knee osteoarthritis. The 50 millesimal potency proved to be more effective, indicating its potential advantage in the management of OA knee joint pain and dysfunction.