International Journal of Homoeopathic Sciences

Background: Homoeopathic medicine Phosphorus is often used in individualised treatment; however, there is no systematic synthesis of what symptom constellations lead to its successful remedy applications in clinical case reports. Purpose: To summarise published case reports in humans where Phosphorus has been successfully used and to examine the symptoms and signs most often used in association with its prescription. Methods: A systematic search of databases (PubMed, Scopus, Web of Science, Google Scholar) and journals in the speciality of homoeopathy up to 22 September 2025 was done. We used case reports on human subjects who were treated with Phosphorus alone with a report of clinical improvement and enough detail of presenting symptoms. Multi-remedy therapy or adjunctive therapy were not used in vitro. Records were screened by two independent reviewers, data (symptoms, potency, outcome) was extracted and the quality of reports measured using CARE/MONARCH criteria. Findings: Out of 172 records identified, 13 case reports were eligible. The conditions that were treated were dermatological, hepatic/gastrointestinal, neurological, and psychiatric disorders. Anxiety/fears (5/13; ~38%), thirst/desire cold drinks (4/13; ~31%), and tendency to bleed (4/13; ~31%), were the most common prescribing symptoms. The cases were mostly dermatological (~54%), hepatic/gastrointestinal (~23%), neurology (~15%) and psychiatry (~8%). The most common potencies that were used were 200C, 30C and 1M. Inference: Case reports are always positive that Phosphorus selection is based on the typical keynotes: anxiety/fears, intense thirst of cold water, propensity to bleeding, burning sensation, and sensitive constitution. These results are in line with classical material medica. No protocol was registered for this review. Despite the constraint of being a case report-based review and possibly being affected by publication bias, the review gives a foundation to more systematic and high-level research of Phosphorus.