International Journal of Homoeopathic Sciences

The microbiota-gut-brain (MGB) axis represents a bi-directional communication system linking the central nervous system, enteric nervous system, immune pathways and gut microbiota. Dysregulation of this axis contributes to functional gastrointestinal disorders, particularly irritable bowel syndrome (IBS). Psychological stress alters motility, permeability and microbial composition, while dysbiosis influences neuroinflammation and mood. Emerging studies suggest that individualized homoeopathic treatment may improve quality of life and symptom severity in IBS, potentially through modulation of stress response and neuroimmune pathways. While initial findings are encouraging, methodological limitations in existing studies necessitate more rigorous research. Strengthening evidence in this area may support the inclusion of homoeopathic approaches within integrative management of gut-brain interaction disorders.