International Journal of Homoeopathic Sciences

Antibiotic resistance in E. coli is a global health concern, with the MCR-1 gene detected in China and a polymyxin B-resistant strain in Brazil. Novel drug discovery approaches and alternative therapies like homoeopathy can help especially using nosodes. Even though Psorinum is a powerful Homoeopathic nosode, it has little to no studies on its antimicrobial activity. Antimicrobial activity of Psorinum 30C and 200C against Escherichia coli O157:H7 is tested using the Kirby-Bauer method with Müeller-Hinton Agar (MHA) as the medium. The zone of inhibition and relative growth inhibition percentage is analysed. Psorinum 200 C showed significant zone of inhibition with relative growth inhibition of 28.57% while Psorinum 30 C showed mild to moderate zone of inhibition with relative growth inhibition of 7.14%.